In Vitro Antiestrogenic Effects of Aryl Methyl Sulfone Metabolites of Polychlorinated Biphenyls and 2,2-Bis(4-chlorophenyl)-1,1- dichloroethene on 17 -Estradiol-Induced Gene Expression in Several Bioassay Systems
نویسندگان
چکیده
*Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, NL-3508 TD The Netherlands; †Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, 3584 CT The Netherlands; ‡Institute for Environmental Studies, Vrije Universiteit, Amsterdam, NL-1081 HV The Netherlands; §Department of Environmental Chemistry, Stockholm University, Stockholm, S-101 06 Sweden; and ¶Department of Zoology, National Food Safety and Toxicology Center, Institute of Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824
منابع مشابه
Distribution of methyl sulfone metabolites of polychlorinated biphenyls and p,p'-DDE in human tissues.
We determined methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) in human adipose, liver, brain, and lung tissues obtained from 11 Belgian individuals (9-62 years of age). The total concentration of MeSO2-CBs (lipid weight basis) decreased in the following order: liver (mean, 9.30 ng/g; range, 1.68-27.03 ng/g lipid) > lung [...
متن کاملPrenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort.
Prenatal exposures to organophosphate pesticides and polychlorinated biphenyls have been associated with abnormal neonatal behavior and/or primitive reflexes. In 1998-2002, the Mount Sinai Children's Environmental Health Center (New York City) investigated the effects of indoor pesticide use and exposure to polychlorinated biphenyls on pregnancy outcome and child neurodevelopment in an inner-ci...
متن کاملEffect of single and repeated in vitro exposure of ovarian follicles to o,p'-DDT and p,p'-DDT and their metabolites.
The aim of the presented study was to compare the effect of o,p'-DDT [1,1-dichloro-2,2-bis-(p,p'-chlorophenyl)-ethylene] and p,p'-DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)-ethane] and their metabolites DDE and DDD on estradiol secretion by ovarian follicles, the target organs of environmental estrogens. Theca interna (Tc) and granulosa cells (Gc) were collected from medium size porcine foll...
متن کاملSHORT COMMUNICATION EFFECT OF SINGLE AND REPEATED IN VITRO EXPOSURE OF OVARIAN FOLLICLES TO o,p’-DDT AND p,p’-DDT AND THEIR METABOLITES
The aim of the presented study was to compare the effect of o,p’-DDT [1,1-dichloro-2,2-bis-(p,p’-chlorophenyl)-ethylene] and p,p’-DDT [1,1,1trichloro-2,2-bis-(p-chlorophenyl)-ethane] and their metabolites DDE and DDD on estradiol secretion by ovarian follicles, the target organs of environmental estrogens. Theca interna (Tc) and granulosa cells (Gc) were collected from medium size porcine folli...
متن کاملSurprising findings following a Belgian food contamination with polychlorobiphenyls and dioxins.
We found that 12.1% of Belgian export meat samples from chicken or pork, unrelated to the PCB/dioxin crisis from 1999, contained more than 50 ng polychlorinated biphenyls (PCBs)/g fat and that 6.5% of samples contain more than 20 ng/g fat for the sum of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and its metabolites. Part of this background contamination stems from imported animal feed ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2002